Effect of Acupuncture at Seven Points of the Skull Base on IL-6,Hcy,BDNF,and Neurotransmitters in Patients with Poststroke Depression of Liver Qi Stagnation Type
LING Mengxin
CHEN Feng
ZHANG Ran
Abstract：Objective:To explore the mechanism of acupuncture at the"seven points on the base of the skull"in the treatment of patients with post-stroke depression of liver qi stagnation type.Methods:Totally 130 patients with poststroke depression of liver qi stagnation type were included and randomly divided into control group and observation group,65 patients in each group.The control group received routine western medicine treatment,while the observation group received acupuncture treatment at the"seven acupoints at the base of the skull"and western medicine treatment.The therapeutic effect was compared after 4 weeks of treatment.Improvements of Pittsburgh Sleep Quality Index(PSQI),Hamilton Anxiety Scale(HAMD)scores,and total score of traditional Chinese medicine symptoms were compared between two groups before and after treatment.And improvements of serum interleukin-6(IL-6),homocysteine(Hcy),serotonin(5-HT),gastrin(GAS),brain-derived neurotrophic factor(BDNF),and cerebral blood flow before and after treatment between two groups.The difference in total effective rate between the two groups was compared,too.Results:After treatment,the serum levels of IL-6 and Hcy in the observation group were lower than those in the control group,while levels of 5-HT,GAS,and BDNF were higher,with statistical difference(P＜0.05);After treatment,the observation group showed lower PSQI score,Hamilton Anxiety Scale(HAMD)score,and traditional Chinese medicine total symptom score(P＜0.05);after treatment,the peak systolic flow velocity of the basilar artery and vertebral artery in both groups increased(P＜0.05),and the improvement in the observation group was more significant than that in the control group(P＜0.05);the total effective rate of the observation group was 96.92％(63/65),higher than that of the control group(83.08％)(P＜0.05).Conclusion:For patients with post-stroke depression of liver qi stagnation type,the combination of"seven acupoints at the base of the skull"acupuncture treatment can alleviate inflammatory reactions,regulate nerve factors,improve cerebral blood flow,and enhance clinical efficacy.
Keywords：acupunctureseven acupoints at the base of the skullpoststroke depressionliver qi stagnation typeIL-6BDNFneurotransmitterscerebral blood flow
Publication Date：2024-11-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 1255-1260 )