Clinical Study on Rheumatoid Arthritis with Heat Toxicity Syndrome Treated by Clearing Heat and Detoxifying Method
YAN Jiao
LIU Defang
LIU Tao
LI Guan
LUO Ting
ZHAO Wenwen
HUANG Xiangyu
GUO Mingyang
Abstract：Objective:To observe the clinical efficacy of clearing heat and detoxifying method in treating rheumatoid arthritis(RA)of heat toxic syndrome.Methods:Totally 120 patients with RA were divided into a treatment group and a control group using the random number table method.The control group received conventional western medicine treatment,while the treatment group further received differential treatment using Suxiao Rebi Decoction(速效热痹饮),Wuteng Ercao Decoction(五藤二草汤),and Sanhuang Yilong Decoction(三黄一龙汤).Both groups were treated for 36 weeks.Two groups were evaluated for pain and disease activity using Visual Analogue Scale(VAS)and Disease Activity Scale(DAS28)before treat-ment,as well as 12 weeks,24 weeks,and 36 weeks after treatment.The levels of C-reactive protein(CRP),erythrocyte sedimentation rate(ESR),tartaric acid phosphatase-5b(TRACP5b),and bone specific alkaline phosphatase(BAP)were measured before and after treatment;besides,X-ray examination was conducted on both hands to obtain Sharp score.Finally,the efficacy evaluation criteria such as ACR70 by American College of Rheumatology(ACR)to observe the efficacy.Results:The VAS and DAS28 scores of the treatment group were lower than those of the control group after 12 weeks,24 weeks,and 36 weeks of treatment(P＜0.05).After 36 weeks of treatment,the treatment group had lower CRP,ESR,TRACP5b,BAP,and X-ray Sharp scores than the control group(P＜0.05).The total effective rate in the treatment group was 98.18％,while the total effective rate of the control group was 73.58％,with a statistical difference(x2=13.654,P=0.000 2).Conclusion:The method of clearing heat and detoxification is used to treat RA with heat toxicity syndrome,which can alleviate the pain of RA patients,inhibit disease activity,reduce inflammatory reactions,and improve bone destruction.
Keywords：clearing heat and detoxifying methodrheumatoid arthritisheat toxicity syndromeSuxiao Rebi DecoctionWuteng Ercao DecoctionSanhuang Yilong Decoction
Publication Date：2024-11-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 1230-1234 )