Effects of Qingzao Jiufei Decoction(清燥救肺汤)on Lung Injury Repair,Biomarkers,and Serum FGF-21 and HIF-1α in Idiopathic Pulmonary Fibrosis
ZHAO Di
ZHAO Tian
XUE Xiaotong
LIANG Ruiting
ZHANG Xinyu
Abstract：Objective:To observe the effects of Qingzao Jiufei Decoction(清燥救肺汤)on lung injury repair in patients with idiopathic pulmonary fibrosis(IPF),as well as its impact on biomarkers,and serum levels of fibroblast growth factor-21(FGF-21)and hypoxia-inducible factor-1α(HIF-1α).Methods:A total of 122 IPF patients were randomly divided into a control group and an observation group,61 patients in each group.The control group received conventional western medicine treatment,while the observation group received additional Qingzao Jiufei Decoction treatment.The clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,6-minute walk test(6MWT),St.George's Respiratory Questionnaire(SGRQ)scores,total lung capacity(TLC),diffusing capacity for carbon monoxide(DLCO),and vital capacity(VC)were compared between the two groups.Levels of matrix metalloproteinase-7(MMP-7),osteopontin,FGF-21,HIF-1α,type Ⅱ alveolar cell surface antigen(KL-6),and interleukin-8(IL-8)were also measured.Results:After treatment,the total efficacy rate was higher in the observation group than in the control group(P＜0.05).The TCM syndrome scores were lower in the observation group(P＜0.05),while the 6MWT performance and SGRQ scores were higher in the observation group(P＜0.05).The levels of TLC,DLCO,and VC were significantly higher in the observation group(P＜0.05).Levels of MMP-7,osteopontin,and KL-6 were lower in the observation group(P＜0.05),while FGF-21 and HIF-1α levels were higher(P＜0.05),and IL-8 levels were lower(P＜0.05)compared to the control group.Conclusion:Qingzao Jiufei Decoction could enhance anti-inflammatory effects and promote lung injury repair in IPF patients,reduce biomarker levels,alleviate disease progression,and improve exercise capacity,quality of life and clinical efficacy.
Keywords：Qingzao Jiufei Decoctionidiopathic pulmonary fibrosislung injury repairbiomarkersosteopontinfibroblast growth factor-21hypoxia-inducible factor-1α
Publication Date：2024-11-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 1223-1229 )