Clinical Study of Tiaoshen Zhiai Formula(调神治癌方)Combined with Psychological Intervention in Treatment of Depression After Ovarian Cancer Surgery

YAO Jialiang; CHENG Xi; TIAN Jianhui; CONG Enchao; YANG Yun; LU Xinyi; ZHANG Long; WANG Ziliang; WU Yan

doi:10.16295/j.cnki.0257-358x.2024.11.004

Abstract：Objective:To observe the clinical effect of"regulating spirit to treat cancer"therapy in which Tiaoshen Zhiai Formula(调神治癌方)is combined with psychological intervention in the treatment of ovarian cancer patients with depression after surgery.Methods:A total of 90 ovarian cancer patients with depression after surgery were included according to the inclusion and exclusion criteria,and by using a random number table were divided into the intervention group treated with Tiaoshen Zhiai Formula combined with psychological treatment and the control group treated with routine Tiaoshen Zhiai Formula treatment,45 patients in each group.One treatment course lasted for 4 weeks,and the patients were treated for 3 courses.The scores of PHQ9 depression scale,GAD-7 anxiety scale,multidimensional fatigue inventory-20(MFI-20),PSQI sleep scale and KPS scale were evaluated in both groups at the 0th and 12th weeks,and the blood routine test,liver and kidney function,and cancer antigen 125(CA125)were detected before and after the intervention.Results:After treatment,the level of CA 125 in the intervention group was significantly lower than that in the control group(P＜0.05).The MFI-20 fatigue scores of the two groups were lower than those before treatment,among which the total fatigue score,physical fatigue score,mental fatigue score,decreased power score,and decreased activity score were significantly decreased(P＜0.01).After treatment,the total score of fatigue,physical fatigue,mental fatigue and reduced activity scores in the intervention group were significantly lower than those in the control group(P＜0.05).The comparison of PSQI sleep scores between the two groups after treatment showed that the scores of sleep disorders and daytime dysfunction in the control group were significantly lower than those before treatment(P＜0.05),and scores of sleep quality,hypnotic drugs,sleep disorders,sleep efficiency and PSQI total score in the intervention group were significantly lower than those before treatment(P＜0.05).The improvement of sleep quality,sleep time,hypnotic drugs,sleep disorders,sleep efficiency,daytime dysfunction score and PSQI total score in the intervention group was significantly better than that in the control group(P＜0.05).The improvement of depression,anxiety and KPS quality of life scores in the intervention group was also significantly better than that in the control group(P＜0.05).Conclusion:The"regulating spirit to treat cancer"therapy consisting of Tiaoshen Zhiai Formula combined with psychological intervention can relieve the negative psychological states such as depression and anxiety,relieve the clinical symptoms such as insomnia and fatigue,and finally improve the comprehensive efficacy.