JIA Yingjie's Experience in Treatment of EGFR-TKIs-Associated Oral Mucositis
MEI Qingyun
KONG Fanming
WANG Ziwei
YU Yongchao
WANG Na
ZHANG Dou
ZHAO Lu
JIA Yingjie
Abstract：EGFR-TKIs(epidermal growth factor receptor-tyrosine kinase inhibitors)-associated oral mucositis is a common adverse reaction in tumor patients after treatment with EGFR-TKIs.Professor JIA Yingjie believes that this disease is located in the oral cavity and is closely related to the heart,the spleen and the kidney,with the basic pathogenesis of deficiency of healthy qi,in combination with blood stasis and toxin,and drug toxicity invasion is the core element contributing to the development of the disease.In the early stage of the disease,the common syndromes include heat accumulation in the heart and the spleen,and latent fire in the spleen and the stomach,which are treated mainly by dispelling pathogenic factors.Daochi Powder(导赤散)is used to treat the syndrome of heat accumulation in the heart and the spleen,and Xiehuang Powder(泻黄散)is used to treat latent fire in the spleen and the stomach.In the later stage of the disease,the common syndromes include yin deficiency and effulgent fire,and deficiency of the spleen and the kidney,which are treated mainly by strengthening the healty qi.Zhibai Dihuang Pill(知柏地黄丸)is used to treat yin deficiency and effulgent fire syndrome,and modified Buzhong Yiqi Decoction(补中益气汤)is used to treat deficiency of the spleen and the kidney syndrome.One proved case is attached.
Keywords：oral mucositisepidermal growth factor receptor-tyrosine kinase inhibitorsaccumulation of heat in the heart and the spleenlatent fire in the spleen and the stomachyin deficiency and effulgent firedeficiency of the spleen and the kidney
Publication Date：2024-10-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 1131-1135 )