Meta-analysis of Correlation Between Traditional Chinese Medicine Constitution and Osteoporosis in Northern and Southern China

WU Xiaorui; LIU Yanqiu; MEI Xiao; WANG Dan; HOU Fengyuan; LIU Ruixia

doi:10.16295/j.cnki.0257-358x.2024.05.010

Abstract：Objective:To explore the distribution characteristics of traditional Chinese medicine(TCM)consti-tution in patients with osteoporosis in the northern and southern China.Methods:Literature on the correlation between TCM constitution and osteoporosis published from April 2009 to August 2023 was screened,and the words"osteoporosis","TCM constitution","tradi-tional Chinese medical constitution"and so on were used as keywords for search.The final literature included in the study was divided into those of northern and southern regions,and the differences between the constitution and osteoporosis data in the literature were analyzed.Results:A total of 19 papers were included in the final study,including 9 in the southern region and 10 in the northern region.The results of Meta-analysis showed that the higher occurrence risk of osteoporosis in southern China were qi deficiency constitution(OR=2.46,95％CI:1.68～3.62),yang deficiency constitution(OR=2.19,95％CI:1.83-2.63).Phlegm-dampness constitution(OR=0.41,95％CI:0.32～0.53)and damp-heat constitution(OR=0.56,95％CI:0.35～0.89)were the protective constitutions.Blood stasis constitution(OR=2.32,95％CI:1.51～3.58),yang deficiency constitution(OR=2.28,95％CI:1.56～3.34)and yin deficiency constitution(OR=1.68,95％CI:1.07～2.64)had a higher risk of osteoporosis in northern China.Conclusion:There are differences in the correlation between constitution and osteoporosis in the northern and southern regions.In the southern region,qi deficiency constitution and yang deficiency constitution are risk factors,while phlegm-dampness constitution and damp-heat constitution are protective factors.In the northern region,blood stasis constitution,yang deficiency constitution,and yin deficiency constitution are risk factors.