Effect of Ruangan Huaji Pill(软肝化积丸)on Fibrosis Index and Inflammatory Factor in Patients with Hepatitis C Cirrhosis of Blood Stasis Type
LIU Yingdong
HE Wei
WANG Chao
LIU Dandan
GENG Xiaoyuan
TIAN Shuilin
Abstract：Objective:To observe the effects of Ruangan Huaji Pill(软肝化积丸)on fibrosis index[aspartate aminotransferase-alanine aminotransferase ratio(AAR)],liver fibrosis index(FIB-4)and inflam-matory factors in patients with ecstatic hepatitis C cirrhosis.Methods:A total of 101 patients with hepatitis C cirrhosis were selected and divided into observation group 50 patients(1 case dropout)and control group 51 cases(2 cases dropouts)according to random number table method.Patients in control group were given conventional western medicine treatment,while patients in observation group were further given Ruangan Huaji Pill treatment.Continuous treatment for 3 months.Levels of interleukin-10(IL-10),stromal cell derived factor 1(SDF-1),chemokine receptor 4(CXCR4),aspartate aminotransferase(AST),alanine aminotransferase(ALT),platelet value(PLT)and type Ⅲprecollagen(P Ⅲ NP),type Ⅳ collagen(CIV),hyaluronidase(HA)and laminin(LN)were detected before and after treatment,AAR,FIB-4 index,liver stiffness,portal venous flow,portal vein diameter,portal vein velocity,and spleen thickness were measured,and TCM syndrome scores and clinical efficacy of the observation group and control group were compared,and adverse reactions occurred during treatment between the two groups were recorded.Results:After treatment levels of IL-10,SDF-1,CXCR4,AST,ALT,PⅢ NP,CIV,HA,LN,scores of FIB-4 index and AAR,liver hardness,portal vein diameter,spleen thickness and TCM syndrome score in observation group were significantly lower than those in control group(P＜0.05).The portal vein velocity,portal venous flow and total effectiveness rate in the observation group were significantly higher than those in the control group(P＜0.05),and no significant adverse reactions occurred in both groups.Conclusions:Ruangan Huaji Pill can improve the levels of anti-inflammatory factors and pro-inflammatory factors,inhibit body inflammation,reduce scores of FIB-4 index and AAR,improve liver fibrosis,reduce liver stiffness,improve liver function,liver hemodynamic indexes and spleen thickness,and improve clinical efficacy.
Keywords：Ruangan Huaji Pillhepatitis C cirrhosisinflammatory factorsFIB-4 indexliver stiffnesshepatic hemodynamics
Publication Date：2023-12-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：8( 1274-1281 )