Correlation Between Traditional Chinese Medicine Syndrome Types and Virulence Factors in Chronic Erosive Gastritis Infected with Drug-Resistant Helicobacter Pylori
LI Tong
WANG Zaijian
LI Huixia
LI Min
ZHANG Qiang
LEI Xue
ZHANG Hongwei
GAO Yuxuan
Abstract：Objective:To explore the characteristics of traditional Chinese medicine(TCM)syndrome differentiation and typing in patients with chronic erosive gastritis(CEG)infected with drug-resistant Helicobacter pylori(Hp),and analyze the clinical characteristics of TCM syndrome types and their correlation with cytotoxin-related gene A(CagA)and vacuolar toxin A(VacA).Methods:A total of 559 patients with CEG infected with drug-resistant Hp were selected as the research subjects,who were divided into 5 TCM syndrome types,namely disharmony between liver and stomach,dampness-heat in the spleen and stomach,deficiency and cold of spleen and stomach,deficiency of stomach yin,and stagnation of gastric collaterals.The age,gender,gastroscopic manifestations and detection results of CagA and VacA of the patients were collected,the clinical characteristics of TCM syndrome type of CEG caused by drug-resistant Hp infection,and the correlation between TCM syndrome type and CagA antibody and VacA antibody were analyzed.Results:The distribution frequency of TCM syndrome types in patients with CEG caused by drug-resistant Hp infection was from high to low:46.15％of dampness-heat in the spleen and stomach syndrome＞25.22％of stagnation of gastric collaterals syndrome＞13.24％of disharmony between liver and stomach syndrome＞11.27％of deficiency of stomach yin syndrome＞4.11％of deficiency and cold of spleen and stomach syndrome.The difference was statistically significant(P＜0.05).There was no significant difference in gender,age and gastroscopic manifestations of CEG patients with different TCM syndrome types of drug-resistant Hp infection(P＞0.05),while the expression of CagA antibody and VacA antibody was significantly different(P＜0.05).Spearman correlation analysis showed that disharmony between liver and stomach syndrome and deficiency and cold of spleen and stomach syndrome were negatively correlated with CagA antibody(P＜0.05).Dampness-heat in the spleen and stomach syndrome was positively correlated with positive VacA antibody(P＜0.05).Conclusions:Dampness-heat in the spleen and stomach syndrome is the main type of TCM syndrome in patients with CEG caused by drug-resistant Hp infection,and deficiency and cold of spleen and stomach syndrome is the minor type.The expression of CagA antibody and VacA antibody can provide objective basis for TCM syndrome differentiation and classification of CEG caused by drug-resistant Hp infection.
Keywords：Helicobacter pylorichronic erosive gastritistraditional Chinese medicine syndrome typeCytotoxin-related gene ACavitation toxin Astomachache
Publication Date：2023-09-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 949-954 )