Experimental Study on the Mechanism of Radix Bupleuri Extract Enhancing Animal Growth by Promoting Slow Wave Sleep
XIE Yan
ZHANG Yunfang
GUO Yunpeng
YIN Na
XU Mengmeng
DING Jiguang
ZHAO Lin
Abstract：Objective:To explore the mechanism of Radix bupleuri extract in promoting the growth of animal body length by adjusting slow wave sleep. Methods:The mice in the medication group was given the Radix bupleuri extract (0.940 mg/kg) and compared with the control group. Changes in the growth of the body length and the content of 5-HT in the brain tissues of mice were observed. At the same time, the rats were also given Radix bupleuri extract, and the changes of slow-wave sleep and changes of growth hormone levels were detected. Results:The extract of Radix bupleuri can promote the body length growth of mice at development stage. After 10 days and 20 days of gavage, the change of body length in the medication group was statistically different compared with the blank group(P＜0.01). The increase of 5-HT content in the medication group was statistically different compared with the blank group(P＜0.01). The slow wave sleep prolongation in the treatment group was statistically different compared with that in the blank group(P＜0.05), and the growth hormone level in the medication group increased significantly compared with the blank group(P＜0.01). 5-HT selective inhibitors can inhibit this change. Conclusion:Radix bupleuri extract can promote the growth of animal body length, and this may be due to the promotion of growth hormone secretion caused by increased 5-HT levels in brain tissue and prolonged slow wave sleep duration.
Keywords：Radix bupleuri extractslow wave sleepgrowth hormonebonebody length
Publication Date：2018-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：4( 412-415 )