Experimental Study of Qiangxin Granules Inhibiting Cardiomyocytes Apoptosis in Rat Model of Chronic Heart Failure with Heart Qi Deficiency ,Blood Stasis and Edema Syndrome
FANG Lijun
LI Heng
HU Wenyu
ZHOU Jie
LIN Jiamao
Abstract：Objective:To study the curative effect of Qiangxin granules(QXP) on inhibiting cardiomyocytes apoptosis of rats with chronic heart failure of heart qi deficiency complicated with blood stasis and edema syndrome(HQD-BS-ES). Methods:Eighty SD rats were randomly divided to normal group(n=20) and chronic heart failure of HQD-BS-ES group(n=60) which was established by administering adriamycin plus propylth-iouracil. And then the latter were randomly divided to 3 groups including model control group(n=18),valsar-tan(VAL) group (n=18) and QXP group (n=18). The survival rate,lactate dehydrogenase (LDH),reactive oxy-gen species (ROS),malondialdehyde (MDA),superoxide dismutase (SOD),apoptosis index and Rac1 relative content were evaluated and compared. Results:Compared with the control group,the survival rate, LDH,ROS,MDA,SOD,apoptosis index and Rac1 re-lative content in other groups improved significantly (P<0.05). Compared with the model group,the su-rvival rate,LDH,ROS,MDA,SOD,apoptosis index and Rac1 relative content of the QXP group improved significantly(P<0.05). Compared to VAL group,the survival rate and LDH of the QXP group showed no statistical difference,while the ROS,MDA,SOD,apoptosis index and Rac-1 relative content of the QXP group improved significantly (P<0.05). Conclusion:QXP has a good effect on inhibiting cardiomyocytes apoptosis induced by oxidative stress ,which could be an important mechanism of QXP for curing chronic heart failure of HQD-BS-ES.
Keywords：Qiangxin granuleschronic heart failureheart qi deficiency complicated with blood stasis and edema syndromecardiomyocytes apoptosisoxidative stress
Publication Date：2018-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 156-160 )