Analysis of Intracerebral Neurotransmitters in Patients with Neurosis of Different Syndromes Using Encephalofluctuogram

ZHONG Hao; ZHENG Long; MA Wentao

Abstract：Objective:To analyze the intracerebral neurotransmitters in the patients with neurosis of different syndromes. Methods:One hundred and thirty hospitalized patients with neurosis were divided into different groups according to the traditional Chinese medicine(TCM)syndrome,and 31 healthy people were as the control group. Encephalofluctuogram was applied to test the patients and the control. Also gamma-aminobu-tyric acid(GABA),glutamate(Glu),acetylcholine receptor(AchR),5-hydroxytryptamine(5-HT),acetylcholine(Ach), excitatory transmitter(EXC),norepinephrine(NE),dopamine(DA),and inhibitory transmitter(INH),9 neuro-transmitters,were tested and the ratio between each neurotransmitter ratio was calculated. Results:In the groups of fire due to liver stagnation and liver fire with spleen deficiency,the value of GABA was signifi-cantly lower than that in the group(P<0.05);in the group of liver stagnation with spleen deficiency,yang deficiency of spleen and kidney,and others,the value of Glu was significantly lower than that in the control (P<0.05);in the groups of yin deficiency of liver and kidney,the value of AchR was significantly lower than that in the control;in the group of the deficiency of heart and spleen,5-HT was significantly higher than that in the group of yin of liver and kidney;in the group of yang deficiency of spleen and kidney,the value of NE was significantly higher than that in the groups of fire due to liver stagnation,liver stagnation with spleen deficiency,deficiency of heart and spleen,other and the control;in the group of fire due to liver stagnation,DA was significantly higher than that in the group of deficiency of spleen and heart;in the group of deficiency of spleen and heart deficiency,yin deficiency of liver and kidney,yang deficiency of spleen and kidney and other,DA was lower than that in the control(P<0.05);in the group of fire due to liver stagna-tion,INH was significantly lower than that in the groups of liver stagnation with spleen deficiency and others (P<0.05). On the ratio of related neurotransmit-ters,in the groups of yang deficiency of spleen and kidney,GABA/Glu was higher than that in the groups of fire due to liver stagnation,liver stagna-tion and spleen deficiency,deficiency of heart and spleen,yin deficiency of liver and kidney,and the control(P<0.05). In the group of liver stagnation and spleen deficiency 5-HT/DA and NE/DA were higher than these in the control(P<0.05). Conclusion:The difference intracerebral neurotransmitterts and the ratio can provide an objective basis for TCM syndrome differentiation of neurosis,and could guide clinical treatment.