Effect of Jiawei Gexia Zhuyu Decoction on Liver Function and Hepatic Fibrosis Index of Model Rats of Hepatic Fibrosis
ZHAO Haijun
LI Yan
ZHAO Luming
ZHANG Yanan
HAN Xiaochun
WANG Yuan
WANG Shijun
Abstract：Objective:To study the effect of Jiawei Gexia Zhuyu decoction(JGZD) on liver fibrosis and its action mechanism.Methods:The rats were divided into normal group,model group,colchicine group and JGZD group,with 10 rats in each group.The colchicine group was given colchicines and the dosage was 1 mg/kg.The JGZD group was given JGZD by gavage and the dosage was equal to that of crude medicine.The normal group and the model group were given saline of the same volume.The organ coefficients of liver was tested and the serum was inspected for getting liver function and liver fibrosis index.The sections of liver tissues were stained by HE to observe the histopathological changes.Results:Compared with the model group,the liver fibrosis of rats in the JGZD group were significantly improved;the organ coefficients of liver of rats in JGZD group were significantly decreased;the levels of alamine aminotransferase (ALT),aspartate aminotransferase(AST),laminin(LN) and hyaluronic acid(HA) in serum of rats in the JGZD group were significantly decreased;the levels of albumin(ALB) and total protein(TP) in serum of rats in the JGZD group were significantly increased.All the above differences were statistically significant(P＜0.05).The histopathological results showed that JGZD could obviously alleviate the pathological damage of the liver.Conclusion:JGZD can alleviate the damage of the liver and reduce the degree of fibrosis of model rats.
Keywords：Jiawei Gexia Zhuyu decoctionliver fibrosisliver functionlamininhyaluronic acidrat
Publication Date：2017-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：4( 407-410 )