A Meta-Analysis of the Efficacy and Safety of Rheumatoid Arthritis Treated with Total Glucosides of Paeony
BAHAERGULI·Litifu
SHI rui
Abstract：Objective:To systematically evaluate the efficacy and safety of total glucosides of paeony for rheumatoid arthritis. Methods:From the CNKI,Wanfang Data and VIP,randomized controlled trials(RCTs) on efficacy and safety of total glucosides of paeony combined with immunosuppressant for rheumatoid arthritis were retrieved. RevMan 5.3 was applied for meta-analysis. Results:Ten references were included with 741 patients. In 9 RCTs,clinical efficacy of the experimental group was better than that of control group(OR=2.97,95%CI 1.63 to 5.60,Z=3.54,P<0.0001). In 6 RCTs,after treatment,the time of morning stiffness were reduced,and in the experimental group,it was reduced more obviously(MD=0.11,95%CI 183.42~60.03,Z=3.61,P<0.0001). In 8 RCTs,after treatment,the number of joint swelling was reduced,and in the experi-mental group,it was reduced more obviously(MD=0.12,95%CI 175.13~62.04,Z=3.72,P<0.0001). In 8 RCTs,after treatment,erythrocyte sedimentation rateps decreased,and in the experimental group it decreased more obviously(MD=0.12,95% CI 179.43~64.05,Z=3.84,P<0.0001). In 9 RCTs,adverse reaction was less in the experimental group. Conclusion:Total glucosides of paeony for rheumatoid arthritis is of better effect and higher safety.
Keywords：total glucosides of paeonyimmunosuppressantrheumatoid arthritisefficacy evaluationsafetymeta-analysis
Publication Date：2017-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：4( 224-227 )