The Influence of Shireqing on Ets-1 mRNA Level in Peripheral Blood Mononuclear Cell of Patients with Psoriasis Vulgaris
ZHANG Xiaojie
SUN Shuna
HUANG Qiteng
ZHAN Yongjiu
ZOU Yongxin
Abstract：Objective:To observe the effect of Shireqing on the mRNA level of peripheral blood mononuclear cell (PBMC) in the patients with psoriasis vulgaris,to study the correlation between transcription factor Ets-1 and psoriasis vulgaris of blood heat type,and to reveal the microscopic mechanism of modified Shireqing. Method:Levels of PBMC ETs-1 mRNA of 28 patients with psoriasis vulgaris of blood heat type and 20 healthy people were detected by real-time quantitative PCR,and the changes on levels of Ets-1 mRNA be-fore and after treatment with modified Shireqing. Result:The level of PBMC Ets-1 mRNA in 28 patients with psoriasis of blood heat type were significantly higher than those in the healthy people (P<0.01). The expression level of Ets-1 mRNA was significantly reduced after the treatment with modified Shireqing (P<0.05). Conclusion:The PBMC Ets-1 mRNA level in patients with blood heat syndrome of psoriasis vulgaris was significantly higher than that of normal people ,which could be significantly reduced after treated with modified Shireqing,suggesting that modified Shireqing may regulate the expression level of transcription factor Ets-1 to indirectly affect T lymphocyte differentiation. Through this mechanism ,Shireqing plays a role in the treatment of patients with psoriasis vulgaris of blood heat type.
Keywords：psoriasis vulgarisblood heat typeEts-1 mRNA of mononuclear cellmodified Shireqing
Publication Date：2017-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 36-38 )