Study on Jiawei Lianli Decoction Preventing Irinotecan-Induced Delayed-Onset Diarrhea
XIAO Jun
TIAN Jing
YAN Lei
Abstract：Objective:To evaluate the preventive effect of Jiawei Lianli decoction on delayed-onset diarrhea caused by irinotecan. Methods:There were 62 patients with advanced colorectal cancer randomly divided into two group,30 in treatment group and 32 in control group. All the patients were given FOLFIRI chemothera-py. Patients in the treatment group were given Jiawei Lianli decoction for 10 days. After the treatment,the following changes in two groups were measured such as the incidence and severity of diarrhea ,tumor remis-sion rate,healthy state(Karnofsky score) and the immune function. Results:The treatment group showed sig-nificantly lower incidence rates of delayed-onset diarrhea and less severity of diarrhea than the control group (P<0.05). There was no difference between two groups on tumor remission rate (P>0.05). After the treatment,the CD3+,CD4+,CD4+/CD8+,natural killer cells and the Karnofsky score were increased in both groups,and they also showed differences between the 2 groups(P<0.05). Conclusion:Jiawei Lianli decoc-tion can prevent the delayed-onset diarrhea caused by irrinotecan,improve the quality of life,and enhance the immune function of the patients with advanced colorectal cancer.
Keywords：Jiawei Lianli decoctionirinotecandelayed-onset diarrheacolorectal cancerlife qualityimmune function
Publication Date：2016-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 1042-1043,1047 )