Study on Correlation between Cervical Liquid-Based Cytology and Biopsy Index Classification and Traditional Chinese Medicine Syndrome and Cervical Cell DNA Ploidy Analysis

ZHANG Xiao; GAO Jing; ZHANG Jinhu

Abstract：Objective:To explore the relationship between cervical intraepthelial neoplasm(CIN) and tradition-al Chinese medicine(TCM) syndromes,and the importance of DNA ploidy analysis system for the diagnosis of this disease. Method:There were 389 people given cervical liquid-based cytology examination,and diag-nosed to determine the clinical TCM syndrome type ,while the remaining specimens were used for DNA ploidy analysis. Results of pathological examination were taken as gold standard. The importance of DNA ploidy for CIN and the TCM syndromes distribution in the disease were analyzed. Results:①In the 247 pa-tients with CIN,spleen deficiency and dampness accounted for 66 cases,yin deficiency and dampness 29 cases,damp heat 67 cases,kidney yang insufficien-cy 29 cases,damp stagnation 56 cases. The distri-bution of CIN in different TCM syndromes had statistical significance(P<0.05). ②In 389 people, atypical squamous cells of undetermined signifi-cance accounted for 169 cases ,atypical squamous cells without HSIL 10 cases,low-grade squamous intraepithelial lesions 132 cases,high-grade squamous in-traepithelial lesions 61 cases,squamous cell carcinoma 17 cases. There were 287 people determined as poly-ploid cervical epthlial cells through DNA ploidy analysis. According to pathological examination ,156 patients were of CIN Ⅰ,54 patients CIN Ⅱ,37 patients CIN Ⅲ,27 patients SCC. CIN Ⅰ and the above were pos-itive,LSIL and the above level were used as standard to assess CIN Ⅰ and the above pathologic changes, with the sensitivity being 66.24%,the specificity 66.96%,the positive predictive value 82.73%,and the nega-tive predictive value 45.56%. DNA ploidy analysis system and DNA polyploid cells were used as the stan-dard to assess CINⅠ and the above pathologic changes,with the sensitivity being 90.15%,the specificity 65.22%,the positive predictive value 86.06%,and the negative predictive value 73.53%. Conclusion:The dis-tribution of cervical intraepithelial lesions in different TCM syndromes was statistically significant ,and DNA ploidy analysis can effectively improve the positive detection rate for screening cervical cancer.