Study on Blood Stasis and Bleeding Correlated with Microcirculation Disturbance in Spontaneously Hypertensive Rats
ZHAO Huichun
ZHANG Fangshen
ZHANG Haiyan
QIN Lin
PENG Xin
ZHANG Yu
YUE Jing
REN Ying
Abstract：Objective:To dynamically observe microcirculation injuries of retina and mesentery in the sponta-neously hypertensive rats(SHRs),to analysis whether blood stasis and bleeding is correlated with microcircu-lation disturbance,and to provide the experimental evidence for clinical diagnosis and treatment. Methods:Rats were divided into the control and model groups. In the model group there were 20 male SHRs and in the control group there were 20 male healthy Wistar rats. Retinal camera and mesenteric microcirculation observation system were used to perform the observation. Ten rats from each group were randomly selected for the observation and hemorheological examination at the age of 6 months and 10 months. Results:In the model group the rats at the age of 6 months and 10 months showed the manifestation of blood stasis ,such as dysmorphic retinal and mesenteric microvessels,decreased microvessels,significantly decreased blood flow, narrowing of microartery,decreased DA/DV,with statistical difference compared with the control group rats (P<0.05 or P<0.01). With the increase of age,blood pressure increased,injury due to blood stasis became serious,and even microangioma and bleeding appeared. Conclusions:With the development of the disease, SHRs could manifest pathological changes like blood stasis and hemorrhage.
Keywords：spontaneously hypertensive ratsretinamesenteriummicrocirculationblood stasis and bleeding
Publication Date：2016-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 985-988,995 )