Systematical Review on Effect of Suanzaoren Decoction Treating Insomnia

LU Aiyangzi; SONG Junsheng

Abstract：Objective:To compare the efficacy and the long term curative effect of Suanzaoren decoction and benzodiazepines treating insomnia. Methods:China knowledge resource integrated database (CNKI) (1979~2013) and VIP journal integration platform (VIP) (1989~2013) and Wanfang database (1998~2013) were searched,and the library of Tianjin university of traditional Chinese medicine were also searched manually to collect the randomized controlled clinical trials of Suanzaoren decoction and benzodiazepines treating insom-nia. Data were retrieved by two researchers indecently,evaluated in accordance with Cochrane Reviewer’s Handbook 5.0,and analyzed using Revman 5.2. Results:There were 20 randomized controlled trials with 2 231 cases . Meta-analysis results showed that:①On the total clinical effective rate:Suanzaoren decoction was better than benzodiazepines [RR=3,95% confidence interval(CI)(2.35,3.84)]. ②On long term curative effect:Suanzaoren decoction was better than benzodiazepines group from the 7th to the 60th day. Conclusion:Suanzaoren decoction was better than benzodiazepines on relieving the clinical symptoms and improving the total efficacy and the long term effect. Due to the low quality of the included studies,more multicenter,ran-domized,double-blind,controlled trials of high quality and large sample size are need to further verify the conclusion.