Treatment of Postmenopausal Osteoporotic Vertebral Compression Fracture by Migu Capsule Combined with Vertebroplasty

XU Zhenqiu; SHI Ying

Abstract：Objective:To determine the related indexes of patients with postmenopausal osteoporotic vertebral compression fracture treated by Migu capsule and vetebroplasty and evaluate the clinical curative effect of this theraputic method. Methods:A total of 90 cases of postmenopausal osteoporotic vertebral compression fracture diagnosed by magnetic resonance imaging(MRI) were randomly divided into two groups:the control group and the observation group,with 45 cases in each group. Both the two groups received vertebroplasty and same basical treatment. The control group was treated with Xianlinggubao capsule and the observation group was treated with Migu capsule. The bone mineral density(BMD) of vertebral body and levels of alkaline phos-phatase(ALP) and bone gla protein(BGP) in serum of the two groups after treatment were compared. And the curative effects of the two groups were also compared. Results:After drug administration,the BMD levels of the control group and the observation group were significantly higher than those before drug administration (P<0.05). The BGP and ALP levels in the serum of patients of the two groups were significantly lower than those before drug administration(P<0.05). After drug administration,the BMD level of the observation group was significantly higher than that of the control group(P<0.05) and the BGP and ALP levels of the observation group were significantly lower than those of the control group(P<0.05). The total effective rate of the control group was 84.4% and the observation group was 100%. The difference was statistically significant (P<0.05). Conclusion:Migu capsule can reverse bone formation and compensatory acceleration of bone metabolism of high turnover type osteoporosis,make the bone metablism return to normal,increase the BMD,promote frac-ture healing and improve the clinical symptoms of postmenopausal osteoporotic vertebral compression fracture.