Effect of Integrated Traditional Chinese and Western Medicine on Serum Lipid Level and Intimamedia Thickness of Carotid Artery in Hyperlipemia Patients

LI Mei; LI Meng; DUAN Lei

Abstract：Objective:To explore the effect of Jianpi Jiangzhuo decoction combined with simvastatin on serum lipid level and intimamedia thickness (IMT) of carotid artery in hyperlipidemic patients. Methods:There were 104 hyperlipemia patients randomly divided into observation group and control group. In control group 20 mg simvastatin was given before sleeping while Jianpi Jiangzhuo decoction 200 mL twice every day besides the 20 mg simvastatin in the observation group. The serum lipid level and(IMT) of carotid artery were observed before and after therapy. Results:In both groups,TG,TC,LDL-C levels decreased after treatment,with statisti-cal difference(P<0.05);In the observation group after the treatment,levels of TG,TC,LDL-C decreased more than those in the control group,with statistical difference(P<0.05),but the increase of HDL-C level was not obvious compared with the control group , without statistical difference ( P>0 . 05 ) . In both groups after the treatment,carotid artery IMT decreased compared before the treatment,with statistical difference(P<0.05). After the treatment, in the observation group,carotid IMT was obviously lower than that in the control group , with statistical difference ( P<0 . 05 ) . Adverse reactions were observed on 1 patient in the control group,and there were no adverse reactions in the observation group. Conclusion:Jianpi Jiangzhuo decoction combined with simvastatin could significantly reduce the serum lipid level and IMT of carotid artery ,showing stronger effects on lowering serum lipid and anti-atherosclerosis.