Study of the Anti-tumor Effect and Mechanism of Strengthening Healthy Qi and Eliminating Pathogenic Factors on Mice Model with Lewis Lung Cancer
QI Yuanfu
Zhang Yingying
LI Huijie
ZHENG Yi
LIU Zhaidong
Abstract：Objective:To study of the anti-tumor effect and mechanism of strengthening healthy Qi and elimi-nating pathogenic factors on mice model with Lewis lung cancer. Method:The Lewis lung cancer mouse model was established,the mic were divided into different groups and given intervention. The anti-tumor rate of each group was calculated,the expression of BCL-2 in tumor cells was measured with immunohistochem-istry,the expressions of caspase-3 mRNA,surviving mRNA were detected with real-time PCR. Results:Qizhen guben formula and Qinlian zhengji formula all had certain anti-tumor effect,with the anti-rate 18.42% and 29.24% respectively,and there were no significant differences between two groups(P>0.05). When compared to the control group,they all could significantly promote the expression of caspase mRNA and down-regulate the expression of BCL-2 survivin mRNA,but the their effect was not better than cisplatin. Conclusion:Qizhen guben formula and Qinlian zhengji formula did possess anti-tumor effect and this effect of Qinlian Zhengji formual was stronger. Their mechanism of action may be related to promoting the expression of caspase mR-NA and down-regulating the expression of BCL-2 and survivin mRNA.
Keywords：strengthening healthy Qieliminating pathogenic factorslung cancermechanismmice
Publication Date：2016-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 61-63 )