Related Study of Substance P and Motilin Expression in Model Rats with Liver-qi Stagnation Syndrome of Chronic Gastritis
CHEN Yu
REN Jian
WANG Xiaoyan
Abstract：Objective:To observe substance P (SP) and motilin (MLT) expression in hypothalamus and gastric antrum of rats with liver-qi stagnation syndrome of chronic gastritis ,and to explore the mechanism of liver-qi stagnation syndrome of chronic gastritis. Methods:Rats were given ammonia,bounded at night,fasting and swam in cold water to establish the model of liver-qi stagnation syndrome of chronic gastritis. All rats were randomly divided into normal group,gastritis group,liver-qi stagnation syndrome group and liver-qi stagnation syndrome of chronic gastritis group. The expression of SP and MLT in hypothalamus and gastric antrum were observed by immunohistochemical method. Result:Compared with the normal group,gastritis group and liv-er-qi stagnation syndrome group,the expression levels of SP and MLT in hypothalamus and gastric antrum of liver-qi stagnation syndrome of chronic gastritis group were lower (P<0.05). Conclusion:The possible neu-robiological mechanism of liver-qi stagnation syndrome of chronic gastritis is due to the changes of SP and MLT. SP and MLT could be regarded as indexes to evaluate the model of liver-qi stagnation syndrome of chronic gastritis.
Keywords：chronic gastritisliver-qi stagnation syndromesubstance P(SP)motilin(MLT)ratanimal exper-iment
Publication Date：2015-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 694-695,698 )