Clinical Observation of Wenshen Xiezhuo Decoction in Treating Asymptomatic Hyper-uricemia of Middle and Old Aged Males

ZHOU Dongqing; WANG Yingjue; GAO Shurong

Abstract：Objective:To observe the clinical efficacy and safety of Wenshen Xiezhuo decoction in the treat-ment of asymptomatic hyperuricemia of middle and old aged males. Methods:Totally 60 cases were divided randomly into two groups: control group in which 30 cases were treated by Ermiao pill ,and treatment group in which 30 cases were treated by Wenshen Xiezhuo decoction ,with a course of 6 weeks. Serum uric acid (SUA),alanine transaminase (ALT),creatinine (Cr),Triglyceride (TG),total cholesterol (CHOL),high density lipoprotein cholesterol (HDL),low density lipoprotein cholesterol (LDL),lipoprotein (α) [Lp (α)] and fasting plasma glucose(FPG) were observed. Results: After treatment,the total effective rates in the treatment group and the control group were 70% and 46.7% respectively,with a significant difference in the efficacy between the two groups(P<0.05). After treatment SUA were all reduced in both groups(P<0.01 and P<0.05). There was not a significant difference after treatment between the groups(P>0.05). In the treatment group, Lp(a) was obviously decreased(P<0.05). In the control group,Lp(α) was also decreased(P>0.05). The TG,CHOL,LDL,GLU,ALT and Cr of the two groups were decreased,but there were not significant differ-ences after treatment. After treatment HDL were all increased ,there were not significant differences. Two groups had no obvious adverse reactions. Conclusion:Wenshen Xiezhuo decoction has positive effects on asymptomatic hyperuricemia,without apparent toxic side effects.