Effect of Borneol on Content of Phenytoin in Blood and Brain Tissues
REN Zhaoyan
ZHANG Weiguo
YANG Ying
TAN Ying
SUN Xiaowei
SUN Mingjiang
Abstract：Objective:To study the effect of phenytoin combined with borneol on content of phenytoin in blood and distribution of phenytoin in brain tissue. Methods:The content of phenytoin in blood and brain tissue when phenytoin was used alone and together with borneol was determined respectively by HPLC. Re-sults:Before the the borneol was added, the contents of phenytoin in rats ’ blood and brain tissue were 9.65 ±0.19 μg/mL and 6.18 ±0.17 μg/mL. when the borneol was added,the contents of phenytoin in rats’ blood and brain tissue increased significantly. Conclusion:Borneol can promote the absorption of phenytoin and help phenytoin to penetrate the blood-brain barrier. It can enhance the effect of phenytoin.
Keywords：borneolphenytoinblood-brain barriercontent determination
Publication Date：2015-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 605-606,617 )