Effect of Huangqin Decoction on Serum MMP-2 and MMP-9 Expression in Advanced Gastric Cancer Patients
HUANG Qian
XIE Fangwei
HUANG Qiaojia
CHEN Xi
CHEN Xiong
LI Xiaoqing
WANG Junhui
OUYANG Xuenong
Abstract：Objective:To discuss the reducing toxicity effect and serum levels of matrix metalloproteinase-2 ( MMP2 ) and matrix metalloproteinase-9 ( MMP9 ) expression in advanced gastric patients treated with Huangqin decoction. Methods:Sixty patients with advanced gastric cancer were randomly divided into experi-mental group and control group,30 cases in each group. The patients were treated with conventional chemotherapy in control group,and conventional chemotherapy and Huangqin decoction in experimental group.The clinical effect and serum levels of MMP-2 and MMP-9 expression were observed. Results:The MMP-2 and MMP-9 expression levels in experimental group were significantly reduced after treatment ,with significant difference on MMP-2 and MMP-9 between the experimental group and the control group. The overall response rate ( RR ) of experimental group and control group were 20 . 0% and 10 . 0% respectively (P=0.278). The disease control rates(DCR) were 76.7% and 70.0% respectively(P=0.165). The improvement of quality of life in the experimental group was better than the control group(P<0.05). Conclusion:Huangqin decoction can provide well effect for advanced gastric cancer ,and its mechanism may be by inhibition of MMP-2 and MMP-9 expression.
Keywords：Huangqin decoctionchemotherapyadvanced gastric cancermatrix metalloproteinase-2 (MMP2)matrix metalloproteinase-9(MMP9)
Publication Date：2015-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 506-508 )