Effect of Xiaobanxia Decoction on Gastrointestinal Hormone in Chemotherapy-induced Pica in Model Rats
ZHANG Yong
YU Gongchang
NIE Ke
Abstract：Objective:In order to explore the anti-emetic mechanism of Xiaobanxia decoction (XBXT),its ef-fect on gastrointestinal hormone level was observed in chemotherapy-induced pica rats. Methods:Sixty male Wistar rats were randomly divided into normal control,XBXT control,cisplatin model,ondansetron,XBXT high dose and low dose groups. Pica model was induced by cisplatin 6 mg/kg i.p.. One hour before and 11 hour after cisplatin injection,each group was gavaged with distilled water,XBXT 0.8 g/kg,ondansetron 1.3 mg/kg, distilled water,XBXT 1.6 g/kg and 0.8 g/kg respectively. After 24 h of cisplatin injection,gastrointestinal hor-mones in serum were measured using ELISA method. Results:Both dosages of XBXT could significantly in-hibit rat pica (P<0.01),and reverse the abnormal increase of somatostatin and VIP (P<0.05) and abnormal decrease of gastrin and motilin(P<0.05). Conclusion:The mechanism of XBXT on the treatment of chemother-apy-induced nausea and vomiting was related to ameliorate the disorders of gastrointestinal hormone.
Keywords：Xiaobanxia decoctionchemotherapy-induced nausea and vomitinggastrointestinal hormonerat
Publication Date：2015-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 454-456 )