Experimental Study on Inhibitory Effect of Hedyotis Diffusa Willd on Lymphatic Metastasis of Mice with Hepatocarcinoma H22
LI Jie
LI Huaizhi
HAN Bingbing
Abstract：Objective:To observe effects of Hedyotis diffusa Willd in treating hepatocarcinoma lymphatic metastasis of mice. Methods:The H22 lymphatic metastasis models were established by subcutaneous injecting H22 cell line into the palmula of right lower limb. The model mice were randomly divided into 5 groups. The blank group was given normal saline daily,and large,medium,small-dose group were given Hedyotis diffusa Willd,and the control group were received cyclophosphamide by intraperitoneal injection daily. The changes of mouse’s body weight,the weight of immune organ,lung metastasis,paw pads transplantation tumor and lymph node metastasis were observed. Results:In Hedyotis diffusa Willd group,body weight and the weight of immune organs increased,lung nodules and lung metastasis tumor growth index were decreased,and the number of lymph node metastases was reduced. Conclusion:Hedyotis diffusa Willd has an inhibitory ef-fect on the metastasis of hepatocarcinoma lymphatic.
Keywords：Hedyotis diffusa Willdhepatocarcinoma H22anti-tumorlymphatic metastasismice
Publication Date：2014-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 914-916 )