Effects of Jiantai Liquid on Cytokine of IL-1 in the Endometrium of Mouse Models During the Peri-implantation Period
GONG Ping
HUANG Guangying
Abstract：Objective:We discussed the effect of IL-1β,IL-1R of mouse models with embryo implantation dysfunction during the peri-implantation period treated with Jiantai liquid. Methods:The embryo implantation dysfunction model was established. Ninety cases were divided into 3 groups. We observed the implantation rate and the number of implantation sites of each group. The protein levels of IL-1β in the endometrium were examined. The mRNA levels of IL-1β,IL-1R in the endometrium were examined. Results:It was demonstrated that the implantation rate and the number of implantation sites of model group were signifi-cantly lower than that of control group(P<0.01). The implantation rate and the number of implantation sites of CHM group were higher than those of model group,but still lower than that of control group(P<0.05). The concentration of IL-1β in model group was significant higher than that of control group and CHM group. The concentration of IL-1β and IL-1RⅠmRNA in model group were significant higher than that of control group. The concentration of IL-1 RⅠ mRNA in CHM group was significant lower than model group , but still higher than that of control group. Conclusion:It is implicated that the possible mechanism of CHM might be to regulate the expression and transcription of IL-1β,IL-1R and improve the microenvironment of endometrium,as well as increase its reception to the embryo.
Keywords：Jiantai liquidimplantation dysfunctionfacilitate implantationIL-1mouse
Publication Date：2014-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：4( 471-474 )