Effect of Shenqi Yixin Formula on Myocardial Apoptosis Index, and Expressions of Bax and Bcl-2 in Chronic Heart Failure Rats
JIN Juan
WU Dan
ZOU Guoliang
LIU Li
Abstract：Objective:To study the effect of Shenqi Yixin formula on myocardial apoptosis index,expression of Bax and Bcl-2 in chronic heart failure rats induced with doxorubicin. Methods:Ninety male rats were randomly divided into six groups: normal control group,model group,enalapril control group,the Qili Qiangxin capsule control group,the low dose Shenqi Yixin formula group,and the high dose Shenqi Yixin formula group. Chronic heart failure rat models were established using doxorubicin. Assay apoptosis rate via terminal deoxynucleotidyl transferase dUTP nick end labeling ( TUNEL ) essay was applied to test the myocardial apoptosis index,and expressions of Bax and Bcl-2 expression were tested with immunohistochemical methods. Results:Myocardial apoptosis indices of chronic heart failure rats in treatment groups were decreased with statistical difference compared with the model group ( P<0 . 05). The expression of Bax in each treatment group cardiomyocytes was decreased while the expression of Bcl -2 gene was increased,with statistical differences compared with the model group (P<0.05);the effect in high dose Shenqi Yixin formula group was the most obvious. Conclusion:Shenqi Yixin formula could modulate apoptotic genes to inhibit apoptosis, and therefore it could slow or reverse ventricular remodeling. Thus it could treat the chronic heart failure.
Keywords：Shenqi Yixin formulachronic heart failureapoptosis
Publication Date：2014-01-01
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：3( 388-390 )