40 Cases of Perimenopausal Syndrome Treated with Integration of Chinese and Western Medicine

BIAN Weihe; ZHANG Xiaoqing; LI Lin; YANG Jing; YING Yu; SHAO Dawei

Abstract：Objective:To evaluate the clinical effects of perimenopausal syndromes caused by tamoxifen treated with integrated Chinese medicine and western medicine. Methods:Eighty patients treated with tamoxifen for more than 1 year,with positive perimenopausal syndromes,with socre>60,were included;the control group was given oral medication of tamoxifen and the treatment group was given oral administration of tamoxifen plus Sugan Ningxin Tiaoyinyang formula;both group were treated for 2 months. The therapeutical effects were evaluated with modified Kuppermann score sheet;and life quality of the patient was evaluated with Karnofsky performance status ( KPS ) score . Results:Fifteen days after treatment , the Kuppermann score began to degrease in the treatment group,whereas there was no obvious change in the control group. Compared to the control group, the Kuppermann scores degreased significantly with statistical differences (P<0.05). There were obvious changes of symptom scores in the treatment group (P<0.01), whereas in the control group,only scores of dizziness,arthralgia,headache and palpitation were decreased;score of each symptom in the treatment group was bettern that in the control group (P<0.01);KPS scores in the treatment group were high compared to the pre-treatment ( P<0 . 05), while there was no significant improvement in the control group (P>0.05); the effect of the treatment group was better than that in the control group. Conclusion:Integration of Chinese and western medicine can effectively reduce the perimenopausal symptoms caused by tamoxifen and improve the life qualities of such patients;besides,it can effectively relieve the side effect of tamoxifen during the treatment for breast cancer.