Distribution and drug resistance of pathogenic microorganisms in dermatology patients

LI Qian; MENG Qingcai

doi:10.13506/j.cnki.jpr.2026.01.015

Abstract：Objective To analyze the distribution and antimicrobial resistance characteristics of pathogens in dermatology patients with skin and mucosal infections at Baoding No.1 Central Hospital,in order to provide guidance for the diagnosis and treatment of clinical infections.Methods Samples from 268 dermatology patients with infections between February 2021 and April 2023 were cultured and identified to analyze the distribution characteristics of pathogens and their resistance to antimicrobial agents.Traditional culture methods and Clinical and Laboratory Standards Institute(CLSI)-recommended antimicrobial susceptibility testing standards were used for detection and evaluation.Results Among the 268 patients,gram-positive bacteria were the main pathogens,with Staphylococcus aureus having the highest detection rate(25.4％).Among gram-negative bacteria,Pseudomonas aeruginosa had the highest detection rate(14.9％).The proportion of fungal infections was low,at only 1.1％.Antimicrobial resistance analysis showed that Staphylococcus aureus had a resistance rate of 92.6％to penicillin G,and Pseudomonas aeruginosa had a resistance rate of 47.5％to ciprofloxacin.Conclusion The types and resistance patterns of pathogens in dermatology infections are diverse,and individualized treatment should be conducted based on the specific pathogen type and antimicrobial susceptibility results.Strengthening the rational use of antibiotics and infection control measures is crucial to reducing the emergence and spread of resistant bacteria.Future research should focus on the application of novel molecular diagnostic techniques and multi-center,large-sample studies to better guide the prevention and treatment of skin infections.