Research progress on the role of natural compounds in regulating ferroptosis in metabolic associated fatty liver disease
TANG Yi
YAN Chulin
DAI Xinli
ZENG Yizhen
QU Bangchen
TAO Liang
Abstract：Ferroptosis is an iron-dependent programmed cell death form driven by lipid peroxidation,plays a pivotal role in the pathogenesis of metabolic associated fatty liver disease(MAFLD).MAFLD is characterized by hepatic lipid metabolism disorder,with disease progression strongly associated with iron overload,lipid peroxidation,and oxidative stress—where the imbalance in ferroptosis regulation could additionally exacerbate hepatic injury and inflammatory respon-ses.Although there are no clinical drugs specifically targeting ferroptosis approved for market currently,natural compounds demonstrate significant potential in intervening ferroptosis to alleviate MAFLD due to their multi-target regulatory properties.This review focused on precisely regulating key ferroptosis pathways by natural compounds,integrating multiple experimental studies to propose innovative strategies for targeted MAFLD therapy.
Keywords：Natural compoundsFerroptosisMetabolic associated fatty liver disease
Publication Date：2026-01-30
Online Publishing Date：2026-03-24(First online date of this platform, not the publication date of the document)
Pages：10( 63-71,102 )