Research progress of traditional Chinese medicine intervention in liver injury induced by valproic acid and its salts
BAI Wanquan
DILRABA Amire
MARZIYA Mamet Tursun
ZHANG Le
Abstract：Valproic acid and its salts(VP As)are first-line broad-spectrum antiepileptic drugs,which can be used in the treatment of a variety of neurological diseases.However,their clinical application is limited due to the severe liver injury they can induce.Traditional Chinese medicine(TCM),mainly from the plant kingdom,most of them are rich in polyphenolic compounds,which have significant antioxidant properties.In recent years,scientific literature has shown that a variety of TCM and their active ingredients can alleviate liver damage caused by VP As,which has attracted extensive attention from scholars at home and abroad.In this paper,the protective effects of single herbs,compound herbs and active ingredients on the induction of liver injury by VP As and underling mechanisms were reviewed.It provides a basis for the clinical application of VPAs and the development of drugs for the treatment of liver injury.
Keywords：Valproic acidHepatotoxicityTraditional Chinese medicineReview
Publication Date：2025-12-30
Online Publishing Date：2026-01-22(First online date of this platform, not the publication date of the document)
Pages：8( 1208-1215 )