Chemical constituents and their anti-inflammatory activities of Acanthopanacis Cortex
ZHANG Xue
BAI Cuihui
NIU Wenshan
DU Yujie
LI Yuwei
MA Yexue
GUO Dongxiao
LIN Yongqiang
LIU Qingzhi
XU Lili
Abstract：Objective To study the chemical constituents and anti-inflammatory activity of Acanthopanacis Cortex(root barks of Acanthopanax gracilistylus W.W.Smith).Methods Compounds were isolated by MCI column,Silica gel column,Sephadex LH-20 gel column,and high performance liquid chromatography from the 70％ethanol extract of Acanthopanacis Cortex.Using 1H-NMR,13C-NMR,MS and other spectroscopic techniques,the chemical structures of the isolated compounds was analyzed.The Griess method was used to test the anti-inflammatory activities of the isolated compounds in the mouse monocyte macrophage RAW264.7 cell release inflammatory factor model induced by lipopolysaccharide.Results 7 compounds were isolated from the ether extract of Acanthopanacis Cortex and identified as:falcarindiol(1),oplopandiol(2),3,4-dimethoxycinnamaldehyde(3),rosin(4),caffeic acid ethyl ester(5),2,3-di(3',4'-methylenedioxybenzyl)-2-butenoic acid-4-lactone(6),and threo-2,3-di(3',4'-methylenedioxybenzyl)-1,4-butanediol monoethyl ester(7).Conclusion Compounds 1～4,6～7 are obtained from this plant for the first time.The results of the anti-inflammatory activity showed that all of the compounds exhibited anti-inflammatory activities.
Keywords：Acanthopanacis CortexChemical constituentsLignansIdentificationAnti-inflammatory activity
Publication Date：2025-12-30
Online Publishing Date：2026-01-22(First online date of this platform, not the publication date of the document)
Pages：5( 1161-1164,1199 )