Research progress of osteoarthritis therapy based on RNA technology
GUO Yixuan
LIN Ang
Abstract：Osteoarthritis(OA)is a chronic degenerative bone disease,mainly manifested by joint pain and swelling that,seriously affect the quality of life.At present,the clinical medication options are limited.The first-line drugs are non-steroidal anti-inflammatory drugs(NSAIDs)and cortisol-based drugs,but they can only provide short-term relief effects and cannot change the progression of the disease.Engineered RNA-based therapies developed using synthetic chemistry and biological tools offer hope for future osteoarthritis treatments.These therapies have long-lasting and effective mechanisms of action and can specifically target the underlying drivers of pathology.In this brief review,we focus on emerging RNA-based technologies with therapeutic potential for OA,including siRNA for gene silencing,microRNA for polygenic regulation,and mRNA for gene supplementation.In conclusion,the purpose of this article is to reveal that RNA-related technologies can provide new treatment methods for osteoarthritis.
Keywords：OsteoarthritisRNA technologysiRNAmicroRNAmRNANovel therapeutics
Publication Date：2025-11-30
Online Publishing Date：2025-12-24(First online date of this platform, not the publication date of the document)
Pages：7( 1091-1097 )