Clinical efficacy of negative pressure wound therapy combined with rhEGF in the treatment of chronic non-healing wounds and its impact on wound healing factors
FU Xiaoxiao
BIAN Chenghao
WANG Huiying
ZHAO Huanjun
Abstract：Objective To explore the clinical effect of negative pressure closed drainage(vacuum sealing drainage,VSD)combined with recombinant human epidermal growth factor(rhEGF)in the treatment of chronic refractory wounds and the influence of wound repair factors on patients.Methods The study selected 80 patients with chronic non-healing wounds admitted to the burn department of our hospital from March 2022 to September 2023.They were randomly divided in-to a control group and a combination therapy group,with 40 patients in each group.All patients received conventional surgi-cal treatment upon admission.The control group was treated with VSD on the basis of conventional treatment,while the com-bined treatment group was treated with VSD combined with rhEGF on the basis of conventional treatment.The clinical effica-cy of the two groups after 2 weeks of treatment was observed and compared.Observe and compare the clinical efficacy of the two groups after 2 weeks of treatment,the pain score of the numerical rating scale(NRS)before and after treatment,the lev-el of infection control,the positive bacterial culture of the wound surface,the level of wound repair factors,the complete healing time of the wound surface,the length of hospital stay and the hospitalization cost of the two groups,etc.Results The comparison showed that the total effective rate of treatment in the combination therapy group was significantly higher than that in the control group(P＜0.05).After 2 weeks of treatment,the NRS pain score,serum CRP,WBC and ESR levels of both groups were significantly decreased compared with those before treatment(P＜0.05),and the NRS pain score and ser-um CRP,WBC and ESR levels of the combined treatment group were lower than those of the control group after 2 weeks of treatment(P＜0.05).The results showed that after 2 weeks of treatment,the positive rate of wound bacteria in both groups was lower than before treatment(P＜0.05),and the rate of wound bacteria turning negative in the combined treatment group(87.50％)was higher than that in the control group(67.50％)(x2=4.588,P=0.032).After 2 weeks of treatment,the lev-els of wound repair factors PDGF,EGF,VEGF and bFGF in both groups were significantly increased compared with those before treatment(P＜0.05),the levels of PDGF,EGF,VEGF and bFGF in the combined treatment group were significantly higher than those in the control group after 2 weeks of treatment(P＜0.05).The comparison showed that the wound healing time and hospital stay in the combined treatment group were shorter than those in the control group(P＜0.05),and the hos-pitalization cost was less than that in the control group(P＜0.05).Conclusion The combination of VSD and rhEGF in the treatment of chronic non-healing wounds demonstrates significant efficacy,further improving the total effective rate of treat-ment,alleviating pain,enhancing infection control,promoting the expression of wound healing factors,accelerating healing,shortening hospital stay,and reducing costs.It is an efficient and economical treatment option.
Keywords：Negative pressure sealing drainageRecombinant human epidermal growth factorChronic refractory woundsClinical effectWound repair factor
Publication Date：2025-09-30
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：6( 926-931 )