Studies on alkaloids constituents from the leaves and twigs of Alstonia macrophylla
LI Ziwei
ZHOU Nan
WU Feiyan
ZHANG Xiaoqi
Abstract：Objective To explore alkaloids from the twigs and leaves of Alstonia macrophylla(Apocynaceae)for structurally unique natural products with drug lead potential.Methods The chemical constituents from the twigs and leaves of A.macrophylla were isolated and purified from by using silica gel,ODS,Sephadex LH-20 column chromatographies,pre-parative HPLC and TLC.The chemical structures were identified based on their physicochemical properties and spectral a-nalysis.Results Twelve alkaloids were isolated and elucidated as 6-oxomacrocarpine B(1),N1-methylburnamine(2),strictamine N4-oxide(3),norfluorocurarine(4),norfluorocurarine N4-oxide(5),N-oxyaffinisine(6),dihydrositsirikine(7),16,17-epoxyisositsirikine(8),pleiomaltinine(9),pleiomalicine(10),macrocarpamine N4′-oxide(11)and villal-stonidine N4′-oxide(12).Conclusion Compound 1 was a new monoterpenoid indole alkaloid,and compounds 2～11 were isolated from this plant A.macrophylla for the first time.
Keywords：Alstonia macrophyllaMonoterpenoid indole alkaloidsChemical constituents6-oxomacrocarpine B
Publication Date：2025-09-30
Online Publishing Date：2025-10-30(First online date of this platform, not the publication date of the document)
Pages：8( 851-858 )