Research advances of 53BP1 in DNA damage response and cancer
WANG Ling
ZHUANG Shentian
YANG Yong
Abstract：In recent years,53BP1 has attracted considerable attention as a key regulator of DNA double-strand break(DSB)repair,playing a crucial role in DNA damage repair and the maintenance of genomic stability.Studies have demonstrated that 53BP1 is not only involved in DNA break repair but also plays a significant regulatory role in tumorigenesis,cancer progression,and drug resistance.This review focused on the structure and function of 53BP1,systematically summarizing recent research advancements and exploring its potential implications for future studies and clinical applications.
Keywords：53BP1DNA damage repairTumor regulationDrug resistance
Publication Date：2025-08-30
Online Publishing Date：2025-09-30(First online date of this platform, not the publication date of the document)
Pages：6( 800-804,813 )