Research progress on sphingolipid metabolism enzymes in liver diseases
ZHU Yujie
ZHOU Yaochuan
NI Jingyang
LI Tingting
Abstract：Sphingolipids are essential for maintaining the integrity of cell membranes and functioning as bioactive lipid signaling molecules,and their various metabolites actively sustain hepatic physiological homeostasis.However,under pathological conditions,the homeostasis of sphingolipid metabolites and regulatory enzymes is disrupted,leading to dysregulation that modulates the occurrence and progression of liver diseases through multiple mechanisms.Extensive studies have shown that targeting ceramide,a central sphingolipid metabolite,and its synthetic metabolic enzymes is one of the effective strategies for treating both acute and chronic liver diseases.This review summarized the roles of several sphingolipid metabolic enzymes in liver diseases and provided an overview of the progress in related targeted therapies,aiming to offer new insights and references for elucidating the pathogenesis of liver diseases and developing clinical therapeutic approaches.
Keywords：CeramideLiver diseasesSerine-palmitoyl transferaseCeramidaseSphingosine kinaseNeutral sphingomyelinase 2
Publication Date：2025-07-30
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：7( 690-695,702 )