Targeting B7-H4:a new strategy to overcome immunosuppression and drug resistance in breast cancer
ZHANG Mengxue
ZHUANG Shentian
YANG Yong
Abstract：Breast cancer,characterized by its high invasiveness and recurrence rate,has emerged as a major disease that severely threatens women's health.Research indicates that B7-H4 is abnormally overexpressed in the majority of human tumor tissues,particularly in breast cancer,and is closely associated with cancer progression and poor clinical prognosis.It not only binds to potential receptors on T cells to exert immunosuppressive effects but also enhances the tumor cells'own ca-pabilities in proliferation,invasion,metastasis,stemness,and anti-apoptosis,thereby promoting tumor progression.However,the regulatory mechanisms remain unclear.This article reviewed the research progress on B7-H4 in breast cancer,aiming to provide new directions for future studies.
Keywords：Breast cancerB7-H4Immune evasionTumor immunotherapy
Publication Date：2025-06-30
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：4( 576-579 )