Safety evaluation of farnesol based on alternative toxicology techniques
GENG Xue
SUN Peilin
WEI Xia
ZHANG Juan
LI Shuixian
CHENG Chunlei
Abstract：Objective To evaluate the safety of acacia alcohol.Methods Derek software,short time exposure test,LL-NA and DPRA were used to predict the toxicity of acacia alcohol.Results According to Derek software,farnesol was pre-dicted to be irritant/corrosive,and further according to the grading standard of LLNA,was predicted as a moderate sensitizer by Derek EC3 model with EC3 value 4.8％.The mean elimination rate of polypeptide in DPRA was 24.21％,resulting farne-sol to be judged as a moderate sensitizer.The result of LLNA displayed that farnesol can cause moderate skin irritation reac-tion,and the EC1.6 value was 2.92％,so farnesol is predicted as a moderate sensitizer.The result of short time exposure test showed no irritation or mild irritation of farnesol.Conclusion Farnesol exhibits potential skin irritation properties and a well-documented sensitization risk.
Keywords：LLNADerek EC3DPRASTE
Publication Date：2025-06-30
Online Publishing Date：2025-08-21(First online date of this platform, not the publication date of the document)
Pages：6( 553-558 )