Research progress on processing methods,pharmacological effects and predictive analysis of quality markers of earth-worm
LIU Fanmin
YIN Jia
LYU Mingyue
WANG Liyuan
WANG Shujing
TAO Yaru
FU Chunsheng
Abstract：Earth-worm is a commonly used animal medicine in clinic,which has the effects of clearing heat,relieving asthma,dredging collaterals and diuresis.It was recorded that it was processed by salt in the Wei and Jin Dynasties.Subse-quently,there are a lot of processing methods,including stir-frying,roasting.Modern pharmacological studies shows that earthworm has the effects of anti-cancer,inhibiting pyroptosis of human umbilical vein endothelial cells,reducing pulmonary hypertension in rats,improving diabetic erectile dysfunction in rats,inhibiting myocardial fibrosis in H9c2 cells,and anti-thrombosis.In this paper,the reported processing methods and pharmacological mechanisms of earth-worm is systematically reviewed.According to the concept of quality markers(Q-Marker),the Q-Marker of earth-worm is predicted and analyzed from the aspects of quality attribute transfer change,chemical composition specificity,measurability,effectiveness and blood components,in order to provide reference for the follow-up study of earth-worm.
Keywords：Earth-wormProcessing methodsPharmacological effectsQuality markers
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 275-281 )