The mechanism of antitumor action of gambogic acid and its research progress in cancer treatment
LIANG Jiawen
YANG Heran
LI Shizhuang
YI Qikun
YUAN Hui
CHEN Haoliang
WANG Yukun
YAN Xueying
Abstract：Garcinia hanburyi is a traditional herbal medicine with anti-inflammatory and hemostatic effects,and gam-bogic acid is the main active ingredient extracted from Garcinia hanburyi with a variety of biological activities,such as anti-cancer,anti-inflammatory,antioxidant,antibacterial,etc.Modern studies have shown that gambogic acid has unique advanta-ges over traditional single-target chemotherapy drugs in targeting,chemosensitization,and reversal of drug resistance.It can exert significant anti-tumor effects through a variety of molecular mechanisms.However,its shortcomings such as high toxici-ty,low solubility,short half-life and other disadvantages limit its clinical application.In order to improve the efficacy of cancer treatment,researchers have used many new nanotechnology to combine other drugs with gambogic acid,and developed many nano-drug delivery systems to overcome these deficiencies of gambogic acid.Therefore,this article summa-rized the latest research results of gambogic acid in the treatment of various tumors in recent years,and reviewed the anti-tumor mechanism of gambogic acid and its nano-drug delivery system for multi-pathway combination therapy,in the hopes of providing a reference for promoting the development and clinical application of gambogic acid nano drug delivery system.
Keywords：Gambogic acidAnti-tumorMechanism of actionDrug delivery systemClinical application
Publication Date：2025-01-27
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：8( 66-73 )