The development and application of lipid nanoparticle in tumor therapy
DU Xiuli
LI Xianjing
Abstract：The global incidence of malignant tumors is increasing year by year,and anti-tumor therapy remains a diffi-cult problem worldwide.As new therapeutic approaches,nucleic acid drugs have opened up novel avenues for oncology treat-ment,but their drugability is limited by in-vivo delivery systems.Lipid nanoparticle(LNP)is the most advanced non-viral delivery system available.LNP encapsulates nucleic acid drugs and delivers them to target cells for effective anti-tumor ac-tions,with the advantages of low cytotoxicity and controllable targeting,and great potential for development.This review cen-ters on the development of LNP technology and provides detailed insights into the preclinical and clinical advancements of LNP in cancer treatment,encompassing the CRISPR/Cas9 system,mRNA vaccine,small interfering RNA(siRNA),Chime-ric antigen receptor(CAR)cell therapy,and other related modalities.Simultaneously,the challenges for further application of LNP in clinical therapy are discussed,with the aim of establishing theoretical frameworks and innovative design concepts for the advancement of more effective and secure in vivo delivery strategies.
Keywords：LNPGene editingmRNA vaccinesiRNA therapyCAR cell therapy
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：10( 1116-1124,1140 )