Research on the quality analysis method of Forsythiae Fructus based on"quality-quantity"double standard
QIU Xiaoxu
WANG Shuai
LI Tianjiao
BAO Yongrui
YANG Xinxin
MENG Xiansheng
Abstract：Objective To establish a dual standard control method of quality-quantity of Forsythiae Fructus herb using the control herb as the reference material for characterization and quantification without relying on multiple controls.Methods High performance liquid chromatography(HPLC)was used to establish the characteristic spectrum of Forsythiae Fructus control herbs,and the characteristic peaks were identified by mass spectrometry;The similarity of the characteristic peaks of the control herbs and the test herbs was compared to clarify the authenticity of the herbs,i.e.,the"quality";The rest of the characteristic peaks were quantified by the reference substances to distinguish the superiority and inferiority of the herbs,in other words,the"quantity".ResuIts The established"quality-quantity"analytical method for Forsythiae Fructus complied with the requirements of methodological investigation,and the similarity between each batch of herbs and the control herbs was above 0.910,and the lower limit of the relative content of the characteristic peaks of chemi-cal constituents of Forsythiae Fructus was stipulated.ConcIusion The method does not depend on multiple controls,and it is clear and fast in judging the authenticity of Forsythiae Fructus herbs,which makes up for the current shortcomings in quality control of Forsythiae Fructus herbs and improves the quality control system of traditional Chinese medicinal materials with a view to promoting the sustainable development of traditional Chinese medicine.
Keywords：Forsythiae FructusReference traditional Chinese medicinal materials"Quality-quantity"double standardCharacterizationForsythoside A
Publication Date：2024-11-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1084-1089 )