Analysis of tigecycline-induced serious adverse drug reactions in Shandong Province in past 10 years
WANG Ting
CUI Xiaokang
LI Min
FENG Rui
REN Jieru
XU Xinping
WU Jiyong
Abstract：Objective To analyze the characteristics of severe adverse reactions caused by tigecycline,and to provide reference for optimizing the treatment plan and reducing the incidence of adverse reactions.Methods A retrospective anal-ysis was performed on 99 cases of severe adverse reactions caused by tigecycline in Shandong Province from January 1,2013 to February 28,2023.Results 99 cases of serious adverse reactions,75 cases of male,female 24 cases;The mean age of the patients was(64±18)years.Hematological system damage ranked first,and the occurrence time ranged from 60 min to 25 d after administration.The results of adverse reactions showed that 13 cases were cured,74 cases were improved,3 cases were not improved,and 9 cases were unknown.The effect on the original disease was not obvious in 47 cases,resulting in 44 cases of prolonged course of disease and 8 cases of exacerbation.Conclusion It is suggested that pharmaceutical care should be carried out for middle-aged and elderly patients and high-risk patients prone to serious adverse reactions.Once serious ad-verse reactions occur,corresponding symptomatic treatment and supportive therapy should be carried out to ensure the safety of medication.
Keywords：TigecyclineSerious adverse reactionShandong Province
Publication Date：2024-10-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 1035-1040 )