Advances in the rodent models of frailty
WEI Cailyu
SHEN Qianhui
GUO Haiyan
XU Jun
PI Rongbiao
Abstract：Frailty is an age-related clinical syndrome characterized by a decline in multi-system physiological functions and increased susceptibility to stressors.The underlying molecular mechanisms of frailty remain incompletely un-derstood.Rodent frailty models can be classified into ① gene-edited developed on basis of disease-related pathology,and②non-gene-edited models that include frailty phenotype or frailty index assessment models and inducible models.This re-view summarized the research progress in rodent frailty models,and analyzes their advantages and disadvantages,and pre-liminary discussion of future development,hoping to provide a reference for frailty-related research.
Keywords：FrailtyRodent animalsAnimal modelFrailty phenotypeFrailty index
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 880-886 )