New method for the preparation of peficitinib hydrobromide
ZHUANG Hongwei
ZHANG Qing
YU Shuai
DENG Chenglong
LI Guofeng
ZHANG Hongwei
Abstract：Objective To introduce a new method for synthesize peficitinib hydrobromide.Methods Peficitinib hydrobromide was synthesized from 4-chloro-1H-pyrrolo[2,3-b]pyridine-5-carbonitrile via the reactions including con-densation reaction,substitution reaction,hydrolysis reaction and salt formation.Results The method had been successfully implemented to prepare the target compound in 61.8％overall yield and 99.2％area purity.Conclusion The method was suitable for industrial production with safety and environmental protection high yield.
Keywords：Peficitinib hydrobromideSynthesisAlkylation
Publication Date：2024-09-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 867-870 )