Structural identification of related substances of Famotidine by UHPLC-Q-Orbitrap HRMS
LI Wenxin
ZHANG Lianyi
WANG Xue
GUO Changchuan
YANG Shujuan
XU Yuwen
Abstract：Objective To identify the related substances of Famotidine.Methods According to Xcalibar and Mass Frontier software,the related substances of Famotidine were detected by ultra high performance liquid chromatography-quadrupole/electrostatic field orbitrap high resolution mass spectrometry(UHPLC-Q-Orbitrap HRMS).Results Three related substances were identified by UHPLC-Q-Orbitrap HRMS.Conclusion The established UHPLC-Q-Orbitrap HRMS method is effective for the identification of the related substances of Famotidine,which is of great useful for its optimization of production process and quality control.
Keywords：FamotidineRelated substancesHRMSStructure identification
Publication Date：2024-06-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 554-558 )