Synthesis and anti-breast cancer activity of phthalimide derivatives of genistein
ZHENG Xing
SUN Linjun
ZHU Yingli
YAO Xu
Abstract：Objective To study the anti-breast cancer activity and mechanism of phthalimide derivatives of genistein in vitro.Methods Phthalimide derivatives of genistein were prepared and their anti-proliferative effects of MCF-7,MDA-MB-231,MDA-MB-435,and MCF-10A cell lines were evaluated by standard MTT method.Molecular docking was used to explore the interaction between the synthesized compounds and estrogen receptor α(ERα).Results Three phthalimide derivatives of genistein were synthesized and their bioactivity and anti-breast cancer mechanism were verified.Conclusion The designed phthalimide derivatives of genistein possess potent anti-breast cancer activity may act as competitive inhibition of ERα and other mechanisms.
Keywords：GenisteinPhthalimideDerivativesAnti-breast cancer activitiesMolecular docking
Publication Date：2024-05-28
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 435-438,454 )